Their star player is Tim Matavz in attack, but Luc Castaignos 网络外围投注is sent to the bench.
Simone Inzaghi rings the changes and needs a reaction after the Derby della Capitale defeat to Roma, which ended their run of nine consecutive victories in all competition.
The Dutch side will be out of the Europa League unless they conquer the Stadio Olimpico and the other game is a draw, because they’d then go head-to-head with Nice in the final round.
The Aquile have already qualified top of their group and are the only team to have won the opening four games in the group phase, but can keep their ambitions of a full house alive.
Vitesse have defender Alexander Buttner suspended, along with inju皇冠外围投注red Maikel van der Werff, Arnold Kruiswijk and Mohammed Osman.
Ciro Immobile, Lucas Leiva, Wallace, Felipe Anderson, Stefan Radu, Davide Di Gennaro and Felipe Caicedo are left in the stands.
Lazio want to make it a perfect start in the Europa League as they host Vitesse with Luis Nani and Jordan Lukaku.
Lazio: Vargic; Patric, Luiz Felipe, Bastos; Basta, Murgia, Luis Alberto, Crecco, Lukaku; Nani; Palombi
Vitesse bench: Houwen, Dabo, Colkett, Bruns, Castaignos, Van Bergen, Oude Kotte
Lazio bench: Strakosha, Guerriero, De Vrij, Lulic, Miceli, Marusic
Vitesse: Pasveer; Lelieveld, Kashia, Mi澳门外围投注azga, Faye; Serero, Ali, Mount, Foor; Rashica, Matavz, Linssen
Ref: Ali Palabıyık (TUR)
It kicks off at 18.00 GMT, you can
Nani gets an opportunity to make his mark in support of striker Simone Palombi, while Lukaku, Patric, Luiz Felipe and Luca Crecco get rare starts.